Acute Submassive Hepatic Necrosis Due to Methyldopa

Cholestatic jaundice due to methyldopa.

The occurrence of hepatitis in patients taking methyldopa was first described over 10 years ago (Gillespie et al., 1962). Though the degree of bile retention in puiblished case reports varies considerably (Tysell and Knauer, 1971) the clinical picture described is generally indistinguishable from viral hepatitis. When the following patient was seen drug-induced jaundice was suspected but as we ...

Bronchial asthma due to alpha-methyldopa.

iron-storage disease, malignant disease, and a history of neck surgery or irradiation. Bone biopsy was not performed in either case because of the absence of any biochemical or radiological evidence of osteomalacia. Our first case is the oldest known patient to present with this disorder, the oldest described elsewhere being an 80-year-old man who presented with confusion.4 Little is known abou...

Acute hepatic necrosis and fulminant hepatic failure.

Fulminant hepatic failure' is defined as severe, acute impairment of hepatic function culminating in hepatic encephalopathy, the encephalopathy being the result of hepatocellular failure and supervening within three weeks of the onset of symptoms*. This definition excludes the hepatic encephalopathy of hepatic cirrhosis and of chronic hepatitis, which produces a slightly different clinical pict...

acute cholangitis due to anomaly of right hepatic artery.

acute cholangitis (ac) is commonly observed in general practice with different causes. we report a case of recurrent ac caused by anomaly of the right hepatic artery, as a rare underlying condition.

Acute fulminant hepatic failure due to colchicine – a rare manifestation of Gloriosa superba poisoning.